The Freefield Pharmacy at the foot of Burgh Road in Lerwick, currently being refurbished, was broken into overnight between Monday and Tuesday.
A quantity of individually marked power tools and toolboxes were stolen. The toolboxes are Makita in make and readily identifiable.
The police are requesting that anyone with information relating to the incident, or who has seen any suspicious activity in the area, contact them on on 101.
The police are also keen to hear from anyone who has been offered such items.